817. Prevention of NSAID-induced gastroduodenal ulcers

Prevention of NSAID-induced gastroduodenal ulcers

The Cochrane Collaboration
Cochrane Reviews

The results of this meta-analysis demonstrate that misoprostol, proton pump inhibitors, and double doses of H2-receptor antagonists are effective at reducing the risk of both gastric and duodenal non steroidal anti-inflammatory (NSAID) medications induced ulcers. In high risk patients, the use of a traditional NSAID + PPI appears equivalent to a COX-2 inhibitor alone. The most effective strategy in high risk GI patients appears to be the combination of a COX-2 inhibitor + PPI.
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Link: http://www2.cochrane.org/reviews/en/ab002296.html